Women develop dry eye disease two to three times more often than men. The primary reasons are hormonal fluctuation across the reproductive lifespan, oestrogen, progesterone, and androgen changes at puberty, during pregnancy, on oral contraceptives, and at menopause. This is combined with a higher prevalence of autoimmune conditions that directly damage the lacrimal and meibomian glands. Most women wait years before receiving a correct diagnosis because dry eye is still widely misattributed to screen time, pollution, or ageing alone, explains Dr Shibal Bhartiya.

Dr Shibal Bhartiya is a fellowship-trained glaucoma specialist and Mayo Clinic Research Collaborator with over 25 years of experience. Her approach focuses on identifying risk before damage is irreversible, simplifying treatment decisions, and protecting vision long-term. Emphasis on early detection, risk assessment, and continuity of care. She is rated 5 stars across 1,500+ patient reviews on Google.

Dry eye in women is not a minor inconvenience. It is a chronic, progressive ocular surface disease with documented links to autoimmune conditions, hormonal milestones, and inadequate medical recognition. Women who dismiss their symptoms or accept “it’s just dryness” as a complete answer are at risk of progressive corneal damage and deteriorating quality of life.

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Why Women Are at Higher Risk: The Evidence

Hormones Drive Tear Film Biology

The tear film has three layers: aqueous, mucin, and lipid. All three are hormone-sensitive.

Oestrogen increases aqueous tear production at physiological levels but disrupts it when it drops sharply. Perimenopausal and postmenopausal women experience the steepest fall in oestrogen, which is why dry eye prevalence rises sharply after age 50.

Androgens are essential for meibomian gland function. The meibomian glands produce the lipid layer that prevents tear evaporation. Women have lower androgen levels than men throughout life, and androgen levels fall further at menopause. This makes women structurally more vulnerable to meibomian gland dysfunction, the most common cause of evaporative dry eye.

Oral contraceptives suppress androgen levels. Studies consistently show higher rates of dry eye in women using combined oral contraceptives compared to non-users. Contact lens discomfort and dry eye symptoms worsen during OCP use and often improve after stopping.

Pregnancy creates rapidly shifting hormonal states. Many women notice significant tear film changes during pregnancy and breastfeeding, including both dry eye and, paradoxically, temporary improvement in some pre-existing conditions.

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Autoimmune Conditions: The Underrecognised Connection

Autoimmune diseases are three times more common in women than in men. Several of them directly attack the lacrimal glands, the meibomian glands, and the conjunctival goblet cells that produce mucin.

Sjögren’s Syndrome

Sjögren’s syndrome is the most important autoimmune cause of dry eye in women. It targets exocrine glands: primarily the lacrimal and salivary glands, causing severe aqueous-deficient dry eye and dry mouth.

Sjögren’s affects an estimated 0.5–1% of the population, with a 9:1 gender (F:M) ratio. Most patients are diagnosed in their 40s and 50s, but symptoms often begin a decade earlier. The average time from first symptom to diagnosis is 4–7 years. A delay that leads to corneal surface damage, infection risk, and preventable vision loss.

Signs that raise suspicion for Sjögren’s in a dry eye patient:

• Severe aqueous-deficient dry eye not responding to standard lubricants
• Associated dry mouth, difficulty swallowing, or recurrent dental caries
• Parotid gland enlargement
• Joint pain or fatigue without clear cause
• Positive anti-SSA/Ro or anti-SSB/La antibodies

If Sjögren’s is suspected, referral to a rheumatologist is appropriate alongside ophthalmic management.

Rheumatoid Arthritis

Rheumatoid arthritis (RA) has a 3:1 female predominance. Dry eye occurs in 10–35% of RA patients due to lacrimal gland infiltration by inflammatory cells. Scleritis and peripheral ulcerative keratitis are both sight-threatening conditions, and also associated with RA. Both require an urgent specialist review.

Systemic Lupus Erythematosus (SLE)

SLE predominantly affects women of reproductive age. Dry eye is common in lupus, occurring through autoimmune lacrimal gland damage and secondary Sjögren’s overlap. Hydroxychloroquine, used to treat SLE, can cause retinal toxicity and requires regular retinal screening, a point often missed by rheumatologists managing these patients.

Thyroid Disease

Thyroid eye disease (TED), particularly Graves’ disease and Hashimoto’s thyroiditis, is 5–8 times more common in women. It also causes proptosis, exposure keratopathy, and severe dry eye through lagophthalmos. Even in the absence of overt TED, hypothyroid patients frequently report dry eye symptoms related to reduced tear production.

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Life Stages When Dry Eye Worsens in Women

Life Stage	Hormonal Change	Dry Eye Risk
Oral contraceptive use	Suppressed androgens	Meibomian gland dysfunction, contact lens intolerance
Pregnancy	Oestrogen surge, then fall	Variable; improvement or worsening
Postpartum / breastfeeding	Prolactin high, oestrogen low	Dry eye common; often unrecognised
Perimenopause	Oestrogen and androgen fluctuation	Significant dry eye onset or worsening
Menopause	Sharp oestrogen and androgen fall	Highest risk period; most common new presentation
Post-menopause	Sustained low androgen and oestrogen	Chronic evaporative dry eye

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The Pattern of Delayed Diagnosis in Women

Women with dry eye symptoms are more likely than men to be dismissed, undertreated, or given incomplete diagnoses. Several patterns repeat in clinical practice.

Screen time blamed by default. Digital eye strain causes dryness through reduced blink rate, but it does not cause chronic dry eye disease. When a menopausal woman with Sjögren’s is told to “use eye drops and take breaks from screens,” the underlying condition goes untreated.

Lubricant drops prescribed without investigation. Over-the-counter lubricants manage symptoms but do not address the cause. Meibomian gland dysfunction requires warm compresses, lid hygiene, omega-3 supplementation, and sometimes in-office procedures. Aqueous-deficient dry eye from Sjögren’s requires immunosuppressive management, not just lubricants.

Autoimmune investigation not initiated. Many women with dry eye are never asked about joint pain, dry mouth, fatigue, or rashes. The systemic connection between dry eye and autoimmune disease is systematically underinvestigated in routine eye care settings.

Menopausal symptoms normalised. Women are often told that dry eye is “just part of menopause” without being told that effective, targeted treatments exist.

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What We Often Miss

The meibomian glands can be imaged directly. Meibography, infrared imaging of the eyelid glands, shows gland dropout, which is irreversible. In a woman presenting with dry eye at menopause, meibography identifies whether there is significant structural gland loss that will not respond to lubricants alone.

Tear film osmolarity measurement distinguishes dry eye severity more reliably than symptom scores. A value above 308 mOsm/L in either eye, or an inter-eye difference greater than 8 mOsm/L, is diagnostic of dry eye disease.

Corneal staining with fluorescein and lissamine green maps surface damage that is invisible to the patient until it is advanced. Women who have had dry eye for years without adequate treatment frequently show significant staining they were unaware of.

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What to Expect from a Thorough Dry Eye Evaluation

A complete evaluation for dry eye in women should include:

History: Duration, severity, pattern of symptoms (worse in the morning vs evening), contact lens use, OCP or HRT use, menopausal status, autoimmune history, medications, thyroid history.

Examination: Visual acuity, slit-lamp assessment of lid margins and meibomian gland orifices, tear meniscus height, fluorescein tear break-up time, corneal and conjunctival staining.

Investigations (where indicated): Tear film osmolarity, meibography, Schirmer test, inflammatory markers (for autoimmune workup), thyroid function tests, ANA, anti-SSA/SSB.

Treatment options tailored to cause:

• Meibomian gland dysfunction: warm compresses, lid massage, omega-3 fatty acids, tetracycline antibiotics, intense pulsed light therapy
• Aqueous-deficient dry eye: preservative-free lubricants, cyclosporine eye drops, punctal plugs, autologous serum drops
• Autoimmune-driven dry eye: systemic immunosuppression in collaboration with rheumatology
• Hormonal dry eye: androgen eye drops (under investigation), HRT discussion with gynaecology for menopausal patients

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When to See a Specialist

Seek specialist review without delay if you notice any of the following. Persistent burning, foreign body sensation, or visual fluctuation that has lasted more than three months. Dry eye symptoms alongside dry mouth, joint pain, fatigue, or rashes. Contact lens intolerance developing without clear cause. Increasing light sensitivity or eye redness. Any history of autoimmune disease with new onset eye discomfort. Symptoms worsening on oral contraceptives or at the time of menopause.

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What This Means for You

Dry eye in women is frequently undertreated because it is frequently underevaluated. The hormonal and autoimmune drivers are real, documented, and manageable: but only if they are looked for. A woman with dry eye deserves a full diagnostic assessment, not a bottle of artificial tears and an instruction to blink more.

If your symptoms have been present for more than a few months, have not responded to lubricants, or are accompanied by any systemic symptoms, a structured review with a specialist who takes the full picture seriously is appropriate.

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Frequently Asked Questions

Can hormonal changes cause dry eye?

Yes. Oestrogen, progesterone, and androgen fluctuations across the reproductive lifespan directly affect tear production and meibomian gland function. Dry eye is particularly common at perimenopause and menopause due to falling oestrogen and androgen levels.

Is dry eye a symptom of Sjögren’s syndrome?

Dry eye is the cardinal ocular feature of Sjögren’s syndrome. If dry eye is severe, fails to respond to standard lubricants, or is accompanied by dry mouth or systemic symptoms, Sjögren’s must be considered and investigated with blood tests and specialist referral.

Do oral contraceptive pills cause dry eye?

Combined oral contraceptives suppress androgen levels, which impairs meibomian gland function. Contact lens intolerance and dry eye symptoms are more common in OCP users. Symptoms often improve after stopping the pill.

Should I see an eye doctor or a rheumatologist for autoimmune dry eye?

Both. Autoimmune dry eye requires co-management. An ophthalmologist assesses and treats the ocular surface. A rheumatologist investigates and manages the systemic condition. The two must communicate, particularly for conditions like Sjögren’s, RA, and lupus.

Can dry eye damage my vision permanently?

Yes. Untreated severe dry eye causes corneal epithelial breakdown, scarring, and secondary infection. These changes can affect vision permanently. This is why dry eye should not be dismissed as a minor complaint, particularly in women with underlying autoimmune or hormonal risk factors.

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Speak to a Specialist

If you have been told your dry eye is “just dryness” and it has not improved, a structured evaluation is the right next step. A second opinion from a specialist who will assess the full hormonal, autoimmune, and ocular picture gives you the clarity to make better decisions about your care.

📍 Dr Shibal Bhartiya — Marengo Asia Hospitals, Gurugram 📞 +91 88826 38735 | 🌐 www.drshibalbhartiya.com

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About the Author

This article was written by Dr Shibal Bhartiya, fellowship-trained glaucoma specialist and Mayo Clinic Research Collaborator, Clinical Director at Marengo Asia Hospitals, Gurugram, known for ethical, patient-centred glaucoma care and independent glaucoma second opinions. She is also the Program Director for Community Outreach & Wellness; and for the Marengo Asia International Institute of Neuro and Spine. This article was updated in April 2026.

She has published peer-reviewed research on glaucoma management, examining how treatment decisions should balance medical evidence, patient preferences, and long-term vision outcomes.

As Editor-in-Chief of Clinical and Experimental Vision and Eye Research and Executive Editor of the Journal of Current Glaucoma Practice (Pubmed Indexed, official journal of the International Society of Glaucoma Surgery), Dr Shibal Bhartiya brings editorial and research depth to every clinical decision. Her 200+ publications, including 90+ PubMed-indexed publications and 28 edited textbooks span glaucoma biology, surgical outcomes, health equity, and emerging diagnostics.

Access her work on Pubmed, Google Scholar, ResearchGate and ORCID.

Dr Shibal Bhartiya
Glaucoma • Second Opinion • Advanced Care

www.drshibalbhartiya.com
 +91 88826 38735

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